Innomech has designed and developed a pilot-scale production system for Aston Particle Technologies (APT) that will help the company accelerate the commercialisation of its innovative dry particle coating technology for use within the pharmaceutical industry.
APT is developing a one-step particle engineering technology to enable ‘challenging’ active pharmaceutical ingredients to be dry powder coated onto carrier particles: without needing heat, solvents or pressure. Target applications for this processing technology breakthrough include the development of new dry powder inhaler formulations, improving the solubility of poorly water-soluble drugs, and developing taste-masking solutions for bitter-tasting drugs.
Innomech has designed the new easy-to-use system to process up to two kilograms of pharmaceutical powders which is a 100-fold increase on the capacity of APT’s existing lab-scale, proof of principle equipment. The system provides a fluidised environment for particle contact and adsorption of cohesive material over coarse particles without the need for solvent and heat. Pressure and temperature sensors, and an ultra-efficient heat exchanger are used to monitor and maintain the required process conditions.